Cotylenin a
WebJun 10, 2016 · Cotylenin A (CN-A, plant growth regulator) combined with PEITC in the treatment of pancreatic cancer can synergistically induce ROS production and lead to cell death mainly due to the induction of ... WebSep 1, 2005 · A synthesis of versatile building blocks for these terpenoids is described, using as key steps ring closing metathesis reaction and Wagner - Meerwein rearrangement for cyclopenta[8]annulene rings system. Sesqui- and sesterterpenes of ophiobolin and fusicoccin families are important synthetic targets because of complexity of structure and …
Cotylenin a
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WebNov 9, 2005 · Rapamycin and cotylenin A cooperatively induced growth arrest in breast carcinoma MCF-7 cells in vitro, and treatment with rapamycin and cotylenin A combined more strongly inhibited the growth of MCF-7 cells as xenografts in vivo than treatment with rapamycin or cotylenin A alone, suggesting that this combination may have therapeutic … WebMar 6, 2009 · Cotylenin A (Fig. 1 a) was originally identified as a cytokinin-like bioactive substance against plants produced by the fungus Cladosporium sp. 501-7W. 8 It was shown to have similar phytotoxic activity on tomato cuttings to the structural homologue fusicoccin A, a wilt-inducing phytotoxin isolated from the fungus Phomopsis amygdali (formerly …
WebAmerican Chemical Society WebFeb 1, 2015 · In the present study, we found that cotylenin A, a plant growth regulator and a potent inducer of differentiation in myeloid leukemia cells, significantly potentiated both ATO-induced inhibition of cell growth in a liquid culture, and ATO-induced inhibition of anchorage-independent growth in a semi-solid culture in human breast cancer MCF-7 …
WebJun 10, 2016 · The treatment of pancreatic cancer, one of the most aggressive gastrointestinal tract malignancies, with current chemotherapeutic drugs has had limited success due to its … WebThe active components, which we call cotylenin A and B, have been isolated, and some of their physical properties determined. WE have found substances in the culture filtrate of a fungus, strain ...
WebMay 13, 2024 · An anticancer drug of fungal origin could be the way. Scientists at Waseda University succeeded in developing a method for a total synthesis of cotylenin A, a plant growth regulator which has ...
WebJan 1, 1998 · The structure of cotylenin A, a potent plant-growth stimulant with the most complex molecule in cotylenins from Cladosporium fungus sp. 501-7W, was analyzed again by HMBC experiments and X-ray crystallography of its diacetyl-dihydroderivative. The previously proposed stereostructure of cotylenin A was thus completely confirmed. iron stop wind spinnersWebAug 14, 2008 · Cotylenin A, a plant growth regulator, and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), are potent inducers of differentiation of myeloid … iron stop wind spinnerWebMar 1, 2014 · Brassicicene K (2) exhibited similar cytostatic profiles to that of cotylenin A (7), and brassicicenes J (1), A (3), B (4), and F (5) exhibited necrotic activity. This is the first report of the seed dormancy breaking activity of brassicicenes in plants, and of necrotic/apoptotic activity in mammalian cells. iron storage bfrWebCotylenin A, a plant growth regulator, and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), are potent inducers of differentiation of myeloid leukemia cells. … iron storm trainerWebMar 8, 2024 · Cotylenin A is a glycosylated diterpene, which was isolated from the metabolites of Cladosporium sp. 501-7W, as a plant growth regulator. 5 Biological … port sheldon party store jenisonWebMar 19, 2024 · Cotylenin A (pictured) was originally isolated from a fungus. It is bioactive and can act as a plant growth regulator and an anti-cancer agent. While its absolute … iron storage boom beachWebAug 1, 2008 · It is demonstrated that cotylenin A and rapamycin rapidly and markedly induced the cyclin G2 gene expression in several cancer cells including MCF‐7 cells. Cotylenin A, a plant growth regulator, and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), are potent inducers of differentiation of myeloid leukemia cells. … iron stops fusion