Web[目的]探讨EphA2在结直肠癌细胞中的生物学功能及其信号调控机制.[方法]qRT-PCR法检测EphA2在结直肠癌细胞系中的表达情况,筛选得到表达量较高细胞株系,利用siRNA沉默该细胞系中EphA2的表达,利用MTT、Transwell、Western blot、qRT-PCR法检测细胞生物学功能变 … WebMembrane-bound erythropoietin-producing hepatocellular receptor tyrosine kinase class A2 (EphA2) is overexpressed in breast, prostate, urinary bladder, skin, lung, ovary and brain cancers. Areas covered in this review: EphA2 overexpression in cancers, its signaling mechanisms and strategies to target its deregulation.

Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer

WebConsidering that EphA2 signaling in cancers is complex, even diametrically opposite, 17–20 the results suggested that EphA2 signaling in SCLC might also be complex. Enlarge this image. FIGURE 1. Ligand-independent phosphorylation of EphA2 is related to chemoresistance of SCLC. WebEphA2 tyrosine kinase is upregulated in many cancers and correlated with poor survival of patients, including those with endometrial cancer. EphA2-targeted drugs have shown … ross burke and knobel reno

Expression of EphA2 and Ephrin A-1 in Carcinoma of the Urinary …

WebEPHA2. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … WebOct 20, 2024 · EphA2 expression was detected in 80-100% of bladder cancer samples and correlated with shorter patient survival. EphA2 was found to be expressed in tumor cells … Webtern of EphA2 in colorectal cancer, where overexpression seemed to be most prevalent in stage 1 and 2 [46]. Similar to other Eph receptors, the EphA2 receptor can be activated through ligand-independent signaling. In glio-blastoma cell lines, the overexpression of EphA2 stimulates the tyrosine kinase activity, which activates ERK, and results stormwatch overland park