2024 P selectin mouse

P selectin mouse

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August undefined, 2024

WebTo our surprise, we found that the E-selectin-binding form of P-selectin glycoprotein ligand-1 (PSGL-1) is expressed on the human bone-metastatic prostate tumor MDA PCa 2b cell line.

P-Selectin Protein, Mouse, Recombinant (His Tag) - Sinobiological

WebE-selectin-targeting Lipo E-X lipid nanoparticles specifically accumulate in the BM of MM-bearing mice and improve the efficacy and reduce the side effects of BTZ in vivo. A MM.1S-GFP-Luc cells (2 × 10 6 cells per mouse) were injected intravenously (IV) into immunodeficient mice (n = 4, NCG mice, 8-week-old, Charles River Laboratories). The ... WebP-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets P-selectin is stored in α-granules . modern baseball band merch

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WebThe Mouse P-Selectin solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. … WebThe Quantikine Mouse soluble P-Selectin (sP-Selectin) Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse sP-Selectin levels in cell culture supernates, serum, and EDTA plasma. It contains NS0-expressed recombinant mouse sP-Selectin and antibodies raised against the recombinant factor. WebApr 14, 2024 · The expression of P-selectin, the phosphorylation of myristoylated alanine-rich C kinase substrate by U46619 or ADP, and the activation of PAC-1 in platelets were inhibited by CSL. Nitric oxide production was increased by CSL in ADP- or U46619-treated human umbilical vein endothelial cells (HUVECs), although excessive endothelin-1 … inno office furniture

APC anti-mouse/rat CD62P (P-selectin) Antibody - BioLegend

WebMouse Immunogen Thrombin activated rat platelets Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Preparation The antibody was purified by … WebThe AC1.2 monoclonal antibody specifically binds to CD62P. CD62P is a 140 kDa type I transmembrane glycoprotein that is also known as P-Selectin, Platelet activation-dependent granule membrane protein (PADGEM), or GMP-140. P-Selectin is stored in the α-granules of platelets and the Weibel-Palade bodies of endothelial cells, and is rapidly transported to … inno on fireWebJul 27, 2011 · Homodimer; disulfide-linked. Interacts with P- and E-selectins, through their lectin/EGF domains. Interaction with P-selectin requires sialyl Lewis X glycan modification and tyrosine sulfation, probably on Tyr-54, for high affinity binding (By similarity). ... A0A0J9YV23_MOUSE: Selplg: 63: A0A0J9YTY7: A0A0J9YTY7_MOUSE: Selplg: 173: … innoo diffuser can\\u0027t take off the lid

"WebThe Mouse P-selectin - IgG Fusion Protein is composed of the signal sequence, the lectin domain, the EGF-like repeat, and the first two complement-binding domains of mouse P … " - P selectin mouse

P selectin mouse

Anti-P-Selectin (CD62P) Antibodies Invitrogen - Thermo Fisher …

WebDec 8, 2024 · P-selectin glycoprotein ligand-1 deficiency augments G-CSF induced myeloid cell mobilization. In p-selectin knock-out mice, several antiinflammatory cytokines were significantly increased following peripheral nerve injury. the presence of endogenous selectin ligands, particularly PSGL-1 on leukocytes, is required for cancer progression. WebMouse P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P-Selectin is translocated to the cell surface within minutes, from alpha granules of platelets or Weibel-Palade bodies of endothelial cells, following stimulation with ...

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WebDec 1, 1998 · To unequivocally examine the role of P-selectin in platelet clearance, we have taken advantage of P-selectin–deficient mice generated a few years ago15 and adapted the techniques of in vivo platelet labeling and platelet transfusion to the mouse. In vivo platelet biotinylation has an advantage over platelet labeling ex vivo in that platelets ... WebApr 7, 2024 · Pre-labeled non-targeted liposomes (DiI) and E-Selectin-targeted Lipo-E-X liposomes (DiD) were mixed in a 1:1 ratio and injected IV at 1 mg/100uL liposomes per mouse.

WebThe Mouse P-Selectin solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the ... WebMouse P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. P-Selectin is translocated to the cell …

WebMouse P-Selectin ELISA Kit (CD62P) (ab200014) is a single-wash 90 min sandwich ELISA designed for the quantitative measurement of P-Selectin (CD62P) protein in cit plasma, serum, cell culture supernatant, and cell culture extracts. It uses our proprietary SimpleStep ELISA® technology. Quantitate Mouse P-Selectin (CD62P) with 4.16 pg/ml ... WebMouse P-Selectin ELISA Kit (CD62P) (ab200014) is a single-wash 90 min sandwich ELISA designed for the quantitative measurement of P-Selectin (CD62P) protein in cit plasma, …

WebP-Selectin, also known as GMP-140, LECAM-3, PADGEM, and CD62P, is a cell surface glycoprotein of the Selectin family and is expressed by activated platelets and endothelial cells (1-3). Mouse P-Selectin cDNA encodes a 768 amino acid (aa) type I transmembrane protein with a signal peptide, a large extracellular domain (ECD), a transmembrane ...

WebApr 20, 2024 · P-Selectin Antibody (1 E 3) is a mouse monoclonal IgG2a, so for a secondary antibody you would want to use an anti-mouse IgG secondary antibody conjugated to either alkaline phosphatase (AP) or horseradish peroxidase (HRP), depending on what detection method being used. We would recommend our mouse IgG binding protein conjugated to … in no other contextWebCD24 and CD162 (PSGL-1) are ligands of CD62P. mAb RB40.34 can block mouse P-selectin binding to its ligands in vitro and in vivo. The antibody was conjugated to BD Horizon BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max near 407 nm and Em Max near 421 nm, BD Horizon BV421 can be excited by the violet ... inn on washington square salem maWebMouse P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. inn on truroWebWestern Blot analysis of P-Selectin (CD62P) in various cell lines using a P-Selectin (CD62P) Polyclonal antibody ( Product # PA5-120169) at a dilution of 1:1,000. 25 µg of lysate or protein were loaded into each lane. A blocking buffer of 3% nonfat dry milk in TBST was used. An HRP conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody was ... innoo humidifier where is it madeWebP-Selectin Protein, Mouse, Recombinant (His Tag): Synonyms CD62P Protein, Mouse; GMP-140 Protein, Mouse; Grmp Protein, Mouse; LECAM3 Protein, Mouse; PADGEM Protein, Mouse P-Selectin Background Information P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. modern baseball pothole lyricsWebJun 4, 2009 · Soluble P-selectin (sP-selectin) is a biomarker for platelet/endothelial activation and is considered a risk factor for vascular disease. sP-selectin enhances procoagulant activity by inducing leukocyte-derived microparticle production and promotes activation of leukocyte integrins. modern baseball tribute concertWebFeb 2, 2024 · Moreover, 1.5-3-month-old P-selectin KO mice showed reduced IL-10-producing leukocytes in blood and a slightly reduced Treg population in the skin. With … inn on tomales bay