WebPINK1 is subsequently cleaved by the inner membrane protease PARL. PINK1 activation: When PINK1 stabilizes at the surface of the mitochondria, it is activated by auto-phosphorylation at Ser228. Ubiquitin phosphorylation: Activated PINK1 phosphorylates ubiquitin at Ser65 on outer mitochondrial membrane substrates. WebPINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. Liu W, Vives-Bauza C, Acn-Perz- R, Yamamoto A, Tan Y, Li Y, Magran J, Stavarache MA, Shaffer S, Chang S, Kaplitt MG, Huang XY, Beal MF, Manfredi G, Li C. PloS one. 2009 4:e4597.
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WebTested Applications: Western, ELISA. Rabbit polyclonal PINK1 antibody. 100% Bioguaranteed. US EN. Applications Products Services Support. SAB1411280; All … WebItem Pink1 Mouse qPCR Template Standard (NM_026880) Company OriGene Technologies; Price Pricing Info Supplier Page View Company Product Page; Catalog Number MK204410; Quantity 1 kit; Type qPCR Template Standards; Target Pink1; Species Mouse; NCBI Full Gene Name PTEN induced putative kinase 1; NCBI Gene Aliases … pdf adobe scanner
PINK1 is activated by mitochondrial membrane potential
WebPINK1 (C-3) is a mouse monoclonal antibody raised against amino acids 282-581 mapping at the C-terminus of PINK1 of human origin. PRODUCT Each vial contains 200 µg IgG 1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin. PINK1 (C-3) is available conjugated to agarose (sc-518052 AC), 500 µg/0.25 ml WebThe ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils mitochondria and upon stress accumulates on the mitochondrial surface where it phosphorylates serine 65 of Ub to activate PRKN and to drive mitochondrial turnover. WebPINK1 Antibodies Antibodies that detect PINK1 can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, … pdf adobe reader chip