WebMar 20, 2015 · One of them, RS7, is a well-known anti-TROP-2 antibody established by Stein et al. [13]. While RS7 did not show antitumor activity in a mouse xenograft model when used as naked antibody, toxin or radioisotope (RI) RS7 conjugates demonstrated significant antitumor activities, which depended on its high internalization activity [14], [15], [16]. WebDec 19, 2014 · TROP2 was first identified as a cell surface marker for trophoblast cells (Lipinski et al., 1981 ), which are highly invasive cells that originate from the outer layer of the blastocyst, aiding implantation and forming a large portion of the placenta.
Full article: Antibody-drug conjugates targeting TROP-2 …
WebFeb 1, 2008 · Human trophoblast cell-surface antigen (TROP2), also known as TACSTD2/GA733-1, M1S1 or EGP-1, encoded by the TROP2 (also known as TACSTD2) gene on 1p32 chromosome, is a transmembrane... Web抗trop-2抗体、其抗原结合片段及其医药用途专利检索，抗trop-2抗体、其抗原结合片段及其医药用途属于抗肿瘤药专利检索，找专利汇即可免费查询专利，抗肿瘤药专利汇是一家知识产权数据服务商，提供专利分析，专利查询，专利检索等数据服务功能。 hauck treatment birmingham
Pr1E11, a novel anti-TROP-2 antibody isolated by …
WebJan 15, 2012 · Background. [ PubMed] Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG 1 monoclonal antibody (mAb) RS7 raised against human non … Web用于治疗癌症的组合疗法专利检索，用于治疗癌症的组合疗法属于·对白血病有特异性的专利检索，找专利汇即可免费查询专利，·对白血病有特异性的专利汇是一家知识产权数据服务商，提供专利分析，专利查询，专利检索等数据服务功能。 WebOct 1, 2012 · RS7 is an internalizing anti-Trop-2 pancarcinoma antibody capable of targeting most epithelial cancers. Because pretargeting strategies could improve the tumor localization of radionuclides, a new anti-Trop-2 × antihapten bispecific antibody for pretargeting, based on humanized RS7, was prepared and evaluated with a radiolabeled … boow png